Pancreatic Cancer Treatment In India
When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy).
Pancreatic cancer is a disease in which normal cells in the pancreas malfunction and begin to grow uncontrollably. These cancerous cells can eventually interfere with proper functioning of the pancreas and metastasize (spread) to other parts of the body.
The pancreas is a pear-shaped gland located in the abdomen between the stomach and the spine. It is about 6 inches in length and is composed of two major components: exocrine and endocrine. The exocrine component, made up of ducts and acini (small sacs on the end of the ducts), produce enzymes, which are specialized proteins released into the small intestine that help the body digest and break down food, particularly fats. It is the cells lining these pancreatic ducts that most frequently turn cancerous. These are called ductal adenocarcinomas of the pancreas and represent the most common subtype of pancreatic cancer.
• Stage 0: No spread. Pancreatic cancer is limited to a single layer of cells in the pancreas. The pancreatic cancer is not visible on imaging tests or even to the naked eye.
• Stage I: Local growth. Pancreatic cancer is limited to the pancreas, but has grown to less than 2 centimeters across (stage IA) or greater than 2 centimeters (stage IB).
• Stage II: Local spread. Pancreatic cancer has grown outside the pancreas, or has spread to nearby lymph nodes
• Stage III: Wider spread. The tumor has expanded into nearby major blood vessels or nerves but has not metastasized.
• Stage IV: Confirmed spread. Pancreatic cancer has spread to distant organs.
• Computed tomography (CT scan): A scanner takes multiple X-ray pictures, and a computer reconstructs them into detailed images of the inside of the abdomen. A CT scan helps doctors make a pancreatic cancer diagnosis.
• Magnetic resonance imaging (MRI):Using magnetic waves, a scanner creates detailed images of the abdomen, in particular the area around the pancreas, liver, and gallbladder.
• Ultrasound : Harmless sound waves reflected off organs in the belly create images, potentially helping doctors make a pancreatic cancer diagnosis.
• Positron emission tomography (PET scan): Radioactive glucose injected into the veins is absorbed by cancer cells. PET scans may help determine the degree of pancreatic cancer spread.
• Percutaneous needle biopsy : Under imaging guidance, a radiologist inserts a needle into the mass, capturing some tissue. This procedure is also called a fine needle aspiration (FNA).
• Endoscopic retrograde cholangiopancreatography (ERCP): A flexible tube with a camera and other tools on its end (endoscope) is put through the mouth to the small intestine, near the pancreas. ERCP can collect images from the area, as well as take a small biopsy with a brush.
• Endoscopic ultrasound : Similar to ERCP, an endoscope is placed near the pancreas. An ultrasound probe on the endoscope locates the mass, and a needle on the endoscope plucks some tissue from the mass.
• Laparoscopy is a surgical procedure that uses several small incisions. Using laparoscopy, a surgeon can collect tissue for biopsy, as well as see inside the abdomen to determine if pancreatic cancer has spread. However, laparoscopy has higher risks than other biopsy approaches.
Surgery-Surgery may involve removing all or part of the pancreas, depending on the location and size of the cancer within the pancreas. If the cancer is still confined to the pancreas' head, or widest part of the pancreas, the surgeon may perform a Whipple procedure. This is an extensive operation where the surgeon removes the head of the pancreas and part of the small intestine, bile duct, and stomach, and then reconnects the digestive tract and biliary system. An experienced surgeon should perform this procedure.
Targeted Therapy-Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy).
Radiation Therapy-Radiation therapy is a cancer treatment that uses high-energy radiation beams to kill cancer cells. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer.
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